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Pioneering the Data Frontier: Digital Battlespace Management

Pioneering the Data Frontier: Digital Battlespace Management

Pioneering the Data Frontier: Digital Battlespace Management

JSTO in the News - A close up of a sign with a sky background
Dr. Hann, Director of the Joint Science and Technology

Dr. Hann, Director of the Joint Science and Technology

Dr. Hann, Director of the Joint Science and Technology Office at the Defense Threat Reduction Agency, examines the liver module of the XCEL project at Los Alamos National Laboratory.

Amy Shurtleff, Ph.D., works in a biosafety level 4

Amy Shurtleff, Ph.D., works in a biosafety level 4

Amy Shurtleff, Ph.D., works in a biosafety level 4 laboratory at USAMRIID. Shurtleff is part of a team that evaluated the protective efficacy of Merck's EBOV vaccine, V920. (Image courtesy of USAMRIID)

How Sweet It Is: GlycoSCORES Speed Drug Development

How Sweet It Is: GlycoSCORES Speed Drug Development

Loading TECAN: Researchers remove a sample plate from the robotic handler. With 384 sample spots (including several for calibration/calibration check), a vast number of permutations and combinations of glycosyl... More

Three protein biomarkers that fluctuate differently

Three protein biomarkers that fluctuate differently

Three protein biomarkers that fluctuate differently in bacterial and viral infections. (Image courtesy of PLOS ONE.)

Next-Generation DNA Delivery Devices

Next-Generation DNA Delivery Devices

A number of DNA vaccine delivery devices are in commercial development which have the potential to overcome these logistical burdens. Several of them will be evaluated by medical personnel at the Delivery of Nu... More

Notional image illustrating how light reflected from

Notional image illustrating how light reflected from

Notional image illustrating how light reflected from butterfly wing scales results in unique data when in the presence of different vapors. Experimental data is shown for dichloropentane (orange), a mustard gas... More

A scientist from the Edgewood Chemical Biological Center

A scientist from the Edgewood Chemical Biological Center

A scientist from the Edgewood Chemical Biological Center (ECBC) separates metal-organic framework (MOF) material from an aluminum surface after electrospinning it. Electrospinning turns a liquid polymer solutio... More

Representation of the Burkholderia pan-genome and

Representation of the Burkholderia pan-genome and

Representation of the Burkholderia pan-genome and sub-components. The purple circle represents the number of unique genes found within the genus Burkholderia; the red circle represents the genes shared among B.... More

Confocal microscope image of a tissue-engineered microvessel

Confocal microscope image of a tissue-engineered microvessel

Confocal microscope image of a tissue-engineered microvessel formed from human brain microvascular endothelial cells in a 3D matrix. Image courtesy of Prof. Peter Searson, Johns Hopkins University.

Prophylactic activity of engineered EcN against P.

Prophylactic activity of engineered EcN against P.

Prophylactic activity of engineered EcN against P. aeruginosa infection. (a) Scheme for pre colonization of EcN in the GI tract followed by P. aeruginosa infection. (b) Colonization of EcN was assessed by fecal... More

An array of blue light-emitting diodes (LED) and a

An array of blue light-emitting diodes (LED) and a

An array of blue light-emitting diodes (LED) and a time-gated specialized camera are used to collect whole body image data from a test mannequin. (Image courtesy of Howard J. Walls, Ph.D., Aerosol Control Group... More

Member of the Special Response Team conducting a Sensitive

Member of the Special Response Team conducting a Sensitive

Member of the Special Response Team conducting a Sensitive Site Assessment Mission wearing a CB Lightweight Integrated Thermal Ensemble (CB Lite) Suit. (Photo courtesy of U.S. Army Research, Development and Eng... More

Schematic representation of a CNT membrane functionalized

Schematic representation of a CNT membrane functionalized

Schematic representation of a CNT membrane functionalized with chemical-threat-responsive polymers. In a safe environment the responsive polymer chains are extended and the material allows rapid transport of wa... More

Courtesy photo - Two men in military uniforms are loading a helicopter
Schematic of integrated liver, heart and lung models

Schematic of integrated liver, heart and lung models

Schematic of integrated liver, heart and lung models interconnected by microfluidic devices that simulate the human circulatory system. (Graphic courtesy of Dr. Anthony Atala, Wake Forest Institute for Regenera... More

Porton Man is a sensor-equipped mannequin capable of

Porton Man is a sensor-equipped mannequin capable of

Porton Man is a sensor-equipped mannequin capable of detecting and evaluating the impact of chemical and biological agents on warfighter uniforms, gloves and other outerwear. (Photo courtesy of Terrence D’Onofrio, Ph.D.)

Edgewood Chemical Biological Center Acting Director

Edgewood Chemical Biological Center Acting Director

Edgewood Chemical Biological Center Acting Director Eric Moore, Ph.D., (left) and Michael Feasel, Ph.D., discuss carfentanil exposure effects and their relation to warfighters. (Official ECBC photo)

(A) Schematic of the confocal laser beam trap
(B) The

(A) Schematic of the confocal laser beam trap (B) The

(A) Schematic of the confocal laser beam trap (B) The laser profile of the trapping hollow cone (C) A particle is trapped at the focal point Figure courtesy of Optics Letters.

Collaboration between Defense Threat Reduction Agency,

Collaboration between Defense Threat Reduction Agency,

Collaboration between Defense Threat Reduction Agency, Chemical and Biological Technologies Department and Wake Forest Institute for Regenerative Medicine resulted in developing organ-on-a-chip technology. The ... More

The rapid design, assembly and validation of paper-based

The rapid design, assembly and validation of paper-based

The rapid design, assembly and validation of paper-based biomolecular sensors for the portable detection of Zika virus is shown here. Using sequence information from online databases, primers for isothermal RNA... More

An Epic Tool for Force Readiness

An Epic Tool for Force Readiness

Proposed list of EpiGrid diseases and release schedule.

Comparison of protection levels provided by two different

Comparison of protection levels provided by two different

Comparison of protection levels provided by two different garments. Garment (1) front and back performance map. Garment (2) front and back performance map.(Courtesy image from Dstl)

Enzymes counter chemical threats

Enzymes counter chemical threats

Enzymes counter chemical threats

The analyte (red) potentially in a complex matrix such

The analyte (red) potentially in a complex matrix such

The analyte (red) potentially in a complex matrix such as blood and urine. The paper itself could be used to directly collect samples from the air. (Graphic courtesy of Trevor Glaros, Edgewood Chemical Biological Center)

Michael Feasel, Ph.D., ECBC, studies the metabolic

Michael Feasel, Ph.D., ECBC, studies the metabolic

Michael Feasel, Ph.D., ECBC, studies the metabolic effects of carfentanil. (Official ECBC photo)

Geographical distribution of the Ebola virus disease

Geographical distribution of the Ebola virus disease

Geographical distribution of the Ebola virus disease outbreak in the Democratic Republic of the Congo as of June 2017. Graphic courtesy of World Health Organization.

Schematic of platelet membrane-coated nanoparticles

Schematic of platelet membrane-coated nanoparticles

Schematic of platelet membrane-coated nanoparticles (PNPs) for the treatment of immune thrombocytopenia purpura (ITP). (A) To fabricate PNPs, the plasma membrane from fresh platelets is derived and then coated ... More

Active site gorge of hAChE phosphonylated by aged soman.

Active site gorge of hAChE phosphonylated by aged soman.

Active site gorge of hAChE phosphonylated by aged soman. The figure was made from a model of aged hAChE–soman conjugate. The ligands are represented as balls and sticks and key active site residues are represen... More

MERS Coronavirus - A close up of a ball of food and a picture of a cell

MERS Coronavirus - A close up of a ball of food and a picture of a cel...

A schematic showing the fluorescent signal obtained from the RNA of the MERS coronavirus using DTRA-developed technology that combines point-ofsampling amplification of the RNA and a signaling beacon made out o... More

Antimicrobial resistance (AMR), or the ability of a

Antimicrobial resistance (AMR), or the ability of a

Antimicrobial resistance (AMR), or the ability of a microbe to resist the effects of medication previously used to treat them, is a growing threat to both public health and the warfighter.

The Climate SOM Process within SAHARA, including mapping

The Climate SOM Process within SAHARA, including mapping

The Climate SOM Process within SAHARA, including mapping and training phases. The training phase includes interim steps which feedback to themselves iteratively; the iteration count is a tuning parameter. The m... More

Members of the Virginia Army National Guard's 34th

Members of the Virginia Army National Guard's 34th

Members of the Virginia Army National Guard's 34th Civil Support Team provide feedback to members of the Tactical All-Hazards Ensemble program team. (Official DTRA photo)

Empowering the Development of Genomics Expertise (EDGE)

Empowering the Development of Genomics Expertise (EDGE)

Empowering the Development of Genomics Expertise (EDGE) offers a suite of analytical tools to assist with mission and threat analysis of biological threats for operational utility. (Graphics by DTRA)

Using Sprayable Slurry, warfighters recently demonstrated

Using Sprayable Slurry, warfighters recently demonstrated

Using Sprayable Slurry, warfighters recently demonstrated CWA vehicle decontamination (using a HUMVEE with simulated contamination) during hands-on, operationally relevant training scenarios at Joint Base Lewis... More

Global distribution of Burkholderia pseudomallei.

Global distribution of Burkholderia pseudomallei.

Global distribution of Burkholderia pseudomallei.

Continuous electrical sensing during bacterial culture.

Continuous electrical sensing during bacterial culture.

Continuous electrical sensing during bacterial culture. (Image courtesy of GE Global Research)

Continuous Liquid Interface Production (CLIP) Process.

Continuous Liquid Interface Production (CLIP) Process.

Continuous Liquid Interface Production (CLIP) Process. Microneedle patches of virtually any design are produced within two to 10 minutes. (Image courtesy of Shaomin Tian, Ph.D., and Sue Mecham, Ph.D.)

Sample to Sequence - A diagram of a computer and a printer
Marines monitoring mission progress inside the

Marines monitoring mission progress inside the

Marines monitoring mission progress inside the representative Combat Operations Center (COC). (Jason Hudson, Global Systems Engineering)

A single dose of Cyto-111 provides protection in mice

A single dose of Cyto-111 provides protection in mice

A single dose of Cyto-111 provides protection in mice at times refractory to antitoxin treatment. Mice lethally intoxicated with 2x LD50 BoNT/A become symptomatic between 6-8 hours after intoxication. Treatment... More

A U.S. Army soldier wears the DTRA-funded CBLITE uniform

A U.S. Army soldier wears the DTRA-funded CBLITE uniform

A U.S. Army soldier wears the DTRA-funded CBLITE uniform during an October 2016 demonstration. Official DTRA Photo.

A researcher demonstrates how the RSDL medical

A researcher demonstrates how the RSDL medical

A researcher demonstrates how the RSDL medical countermeasure is applied ot the skin.

Official DTRA graphics - A number of different screens on a green background
A new project funded by the DTRA’s Joint Science
and

A new project funded by the DTRA’s Joint Science and

A new project funded by the DTRA’s Joint Science and Technology Office and conducted by a team of Lawrence Livermore National Laboratory (LLNL) scientists have created 'second skin,' a new material that is brea... More

Heatmaps representing the members of the top set of

Heatmaps representing the members of the top set of

Heatmaps representing the members of the top set of genes in I interferon (IFN) induction (left), IFN response (middle) and antioxidative response (right) signalling pathways in A549 cells 96 h.p.i. with hRSV N... More

Chemical distribution profiles in stratum corneum (SC)

Chemical distribution profiles in stratum corneum (SC)

Chemical distribution profiles in stratum corneum (SC) after 15 and 60 min of exposure on normal skin. High concentration of chemical remained in 2 μm thickness to the skin surface within 60 minutes of exposure... More

Ebola Virus Disease, US Navy Photogrpah

Ebola Virus Disease, US Navy Photogrpah

When Ebola virus disease (EVD) reared its head in May in the Congo, the world was armed with the rVSV-ZEBOV vaccine thanks to interagency collaboration efforts by the Defense Threat Reduction Agency’s Chemical ... More

Marburg virus particles (in blue) and sperm originating

Marburg virus particles (in blue) and sperm originating

Marburg virus particles (in blue) and sperm originating from the seminiferous tubule, a site of immune privilege and sperm production in the testes, of a non-human primate that survived Marburg virus infection.... More

This chart shows VX dose lethality curves in animals

This chart shows VX dose lethality curves in animals

This chart shows VX dose lethality curves in animals decontaminated with either RSDL or Veriox two minutes after cutaneous exposure.

Integrated Early Warning includes a family of chemical

Integrated Early Warning includes a family of chemical

Integrated Early Warning includes a family of chemical and biological defense systems. A fixed site example is depicted above. (Official DTRA image)

Using Sprayable Slurry, warfighters recently demonstrated

Using Sprayable Slurry, warfighters recently demonstrated

Using Sprayable Slurry, warfighters recently demonstrated CWA vehicle decontamination (using a HUMVEE with simulated contamination) during hands-on, operationally relevant training scenarios at Joint Base Lewis... More

The auto-inductive cascade for the detection of nerve

The auto-inductive cascade for the detection of nerve

The auto-inductive cascade for the detection of nerve agent surrogate, DFP, through fluoride (signal) amplification. Figure courtesy of Chemistry - A European Journal

Tony Buhr, Ph.D., a biologist at NSWCDD, works at a

Tony Buhr, Ph.D., a biologist at NSWCDD, works at a

Tony Buhr, Ph.D., a biologist at NSWCDD, works at a biological safety cabinet on DTRA-funded work on biological warfare agents.

Journal of Chemical and Biological Defense

Journal of Chemical and Biological Defense

Journal of Chemical and Biological Defense

Marburg virus particles (in blue) and sperm originating

Marburg virus particles (in blue) and sperm originating

Marburg virus particles (in blue) and sperm originating from the seminiferous tubule, a site of immune privilege and sperm production in the testes, of a non-human primate that survived Marburg virus infection.... More

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